Teicoplanin and Colistin Induced Nephrotoxicity in A Patient of Septicaemia A Case Report With Emphasis on Morbidity
Teicoplanin and Colistin Induced Nephrotoxicity in A Patient of Septicaemia
Keywords:
Adverse Drug Reaction, Colistin, Nephrotoxicity, TeicoplaninAbstract
Teicoplanin is a glycopeptides antibiotic active against a broad spectrum of gram positive bacteria with negligible action on Gram negative bacilli. Colistin is polymixin which is active against Gram negative organisms only. Nephrotoxicity has been reported with both Teicoplanin and Colistin. A 52 year old patient diagnosed with septic shock following fecal peritonitis was prescribed Teicoplanin, Meropenem and Colistin. Meropenem was omitted after results of culture sensitivity and other two drugs were continued. This patient had a rise in creatinine levels after 10 days of therapy. Teicoplanin was discontinued on 13th of therapy with improvement in patients condition. Hence physicians need to be aware of this interaction of added nephrotoxicity when combining these two antimicrobials. [Shikha S NJIRM 2017; 8(4):106-108]
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