A Case Report Of Linezolid (Lzd) Induced Complete Myelosuppression
Linezolid (Lzd) Induced Complete Myelosuppression
Keywords:
Linezolid (Lzd), Myelosuppression, SepticaemiaAbstract
Linezolid (Lzd) is an oxazolidinone group of antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA). Lzd is associated with adverse haematological effects particularly thrombocytopenia. But pancytopenia and complete myelosuppression is a rare adverse reaction. This is a case report of a 50-year male patient diagnosed as Lower limb cellulitis with septicaemia and was started on Tab. Lzd 600mg BD along with other drugs and supportive treatments. He developed pancytopenia after 4 days of treatment. Lzd was stopped. Patient’s blood count improved significantly after 7 days of drug withdrawal. Hence physicians need to be aware of this rare but serious side effect of Lzd and the importance of routine haematological monitoring to decrease the morbidity and mortality. [Vedang T NJIRM 2017; 8(1):126-128]
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