Secondary Malignancies Developing After Acute Lymphoblastic Leukemia And Its TreatmentWith Constitutional Mismatch Repair Deficiency Syndrome In Siblings
Secondary Malignancies After ALL & Treatment
Keywords:
Alveolar Soft part Sarcoma, Constitutional mismatch repair deficiency syndrome, Acute Lymphoblastic Leukemia, Neural tumorAbstract
Background & Objectives: Acute Lymphoblastic Leukemia (ALL) is the most common childhood malignancy,
with an annual rate of 3 to 4 cases per 1,00,000 children. ALL patients are treated with chemotherapeutic agents and
cranial irradiation. Long-term sequelae of treatment are impaired intellectual and psychomotor functioning,
neuroendocrine abnormalitites, impaired reproductive capacity, cardiotoxicity and second malignant neoplasms are
being reported with increased frequency in the survivors. Among second neoplasms observed after treatment of ALL,
central nervous system (CNS) tumors in patients treated with cranial irradiation are the most common. Others are
Lymphoma, Acute Myeloid Leukemia (AML) and Thyroid Cancer. Methodology & Results: We are reporting four cases
,who developed ALL at the age of 8,6,4 and 25 years respectively(among that case 1 & case 2 are siblings) and were
treated with chemotherapy and cranial irradiation. They developed Astrocytoma Grade-4 , Alveolar Soft-Part
Sarcoma(ASPS) , Anaplastic Large Cell Medulloblastoma & Ewing’s Sarcoma at, 12 , 15, 8, 12 & 26 years of age
respectively. Conclusion: Oncologists should make sure about the radiation doses before starting treatment and they
should keep CMMR-D as a possibility in pediatric patients with siblings having h/o malignancy. [Modi M NJIRM 2016;
7(2):44-51]
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Michael E. Trigg, Paul S. Gaynon and Leslie L.
Robison. Low incidence of second neoplasm
among children diagnosed with acute
lymphoblastic leukemia after 1983.blood.2002;
99:4257-4264
2. Dalton VMK, Gelber RD, Li F, Donnelly MJ, Tarbell
NJ, Sallan SE. Second malignancies in patients
treated for childhood acute lymphoblastic
leukemia. J Clin Oncol. 1998;16:2848-2853.
3. Neglia JP, Meadows AT, Robison LL, et al. Second
neoplasms after acute lymphoblastic leukemia in
childhood. N Engl J Med. 1991;325:1330-1336.
4. Katharina Wimmer, Christian P. Kratz
,Constitutional mismatch repair-deficiency
syndrome, Haematologica May 2010 95: 699-701;
doi:10.3324/haematol.2009.021626
5. Katharina Wimmer, Christian P Kratz, Hans F A
Vasen, Olivier Caron, Chrystelle Colas, Natacha
Entz-Werle, Anne-Marie Gerdes, Yael Goldberg,
Denisa Ilencikova, Martine Muleris, Alex Duval,
Noémie Lavoine, Clara Ruiz-Ponte, Irene Slavc,
Brigit Burkhardt, Laurence Brugieres, on behalf of
the EU-Consortium Care for CMMRD (C4CMMRD),
Diagnostic criteria for constitutional mismatch
repair deficiency syndrome: suggestions of the
European consortium ‘Care for CMMRD’
(C4CMMRD), Cancer genetics, J Med Genet
2014;51:6 355-365 Published Online First: 15 April
2014 doi:10.1136/jmedgenet-2014-102284
6. Daewon Joh, M.D., Bong Jin Park, M.D., Young Jin
Lim, M.D. Radiation induced Glioblastoma
Multiforme in a Remitted Acute Lymphocytic
Leukemia patient. J Korean Neurosurg Soc 50:235-
239, 2011.
7. Milena Maule, Ghislaine Scelo, Guido Pastore, Paul
Brennan, Kari Hemminki, Elizabeth Tracey, Risto
Sankila, Elisabete Weiderpass, Jorgen H. Olsen,
Mary L. McBride, David H. Brewster, Vera Pompe-
Kirn, Erich V. Kliewer, Kee Seng Chia, Jon M. Tonita,
Carmen Martos, Jon G. Jonasson, Franco Merletti,
Paolo Boffetta. Risk of Secondary malignant
neoplasms after Childhood Leukemia and
Lymphoma: An International Study. J Natl Cancer
Inst. 2007;99:790-800.
8. Kirit C. Shah, Vedantam Rajshekhar. Glioblastoma
Multiforme in a child with Acute Lymphoblastic
Leukemia : Case report reviw of literature. Neurol.
India 2004;52:375-377.
9. Muzumdar D P, Desai K, Goel A. Glioblastoma
Multiforme following prophylactic cranial
irradiation and intrathecal methotrexate in a child
with Acute Lymphoblastic Leukemia : A case
report. Neurol. India 1999;47:142-144.
10. Michelle De Padua, VijayAnand Reddy and
Manohar Reddy. Cerebral atypical teratoid
rhabdoid tumour arising in a child treated for acute
lymphoblastic leukemia. BMJ case Rep.2009;
2009:bcr08.2008.0601.
11. Haberler C, Laggner U, CzechT, et al.
Immunohistochemical analysis of INI1 protein in
malignant CNS tumours: Lack of INI1 expression in
atypical teratoid/rhabdoid tumours and a fraction
of primitive neuroectodermal tumours without
rhabdoid phenotype. Am J Surg Pathol 2006; 30 :
1462-8[ PubMed: 17063089]
12. H F AVasen,Z Ghorbanoghli,F Bourdeaut, O
Cabaret, O Caron, A Duval, N Entz-Werle, Y
Goldberg, D Ilencikova, C P Kratz, N Lavoine, J
Loeffen, F H Menko, M Muleris, G Sebille, C Colas ,
B Burkhardt, L Brugieres, K Wimmer, on behalf of
the EU-Consortium Care for CMMR-D (C4CMMR-D)
, Guidelines for surveillance of individuals with
constitutional mismatch repair-deficiency
proposed by the European Consortium “Care for
CMMR-D†(C4CMMR-D) , Cancer genetics, J Med
Genet 2014;51:283-293 doi:10.1136/jmedgenet-
2013-102238
13. Baas AF, Gabbett M, RimacM, Kansikas M, Raphael
M, Nievelstein RA, Nicholls W, Offerhaus J, Bodmer
D, Wernstedt A, Krabichler B, Strasser U, Nyström
M, Zschocke J, Robertson SP, van Haelst MM,
Wimmer K, Agenesis of the corpus callosum and
gray matter heterotopia in three patients with
constitutional mismatch repair deficiency
syndrome.
14. C P Kratz, S Holter, J Etzler, M Lauten, A Pollett, C
M Niemeyer, S Gallinger, K Wimmer,
Rhabdomyosarcoma in patients with constitutional
mismatch-repair-deficiency syndrome, Mutation
report, . J Med Genet 2009;46:418-420
doi:10.1136/jmg.2008.064212
15. Catherine Cullinane,MA, Paul S. Thorner, M.D.,
Ph.D.,Mark L.Greenberg, M.D., t Yim, Kwan Ng
,B.Sc., Margarete Kumar,B.Sc., and Jeremy Squire,
Ph.D.,
16. Molecular Genetic,Cytogenetic,and
Immunohistochemical Characterization of Alveolar
Soft-Part Sarcoma ,Implications for Cell of Origin.Cancer (Impact Factor: 4.9). 11/1992; 70(10):2444
– 2450
17. Argani, Pedram M.D.; Lal, Priti M.D.; Hutchinson,
Brian M.A.; Lui, Man Yee B.A.; Reuter, Victor E.
M.D.; Ladanyi, Marc M.D. Aberrant Nuclear
Immunoreactivity for TFE3 in NeoplasmsWith TFE3
Gene Fusions: A Sensitive and Specific
Immunohistochemical Assay, American Journal of
Surgical Pathology:June 2003 - Volume 27 - Issue 6
- pp 750-761
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Published
2018-02-06
How to Cite
Modi, M., Patel, T., Trivedi, P., Anand, M., Dalsaniya, S., Varlekar, T., & Jetly, D. (2018). Secondary Malignancies Developing After Acute Lymphoblastic Leukemia And Its TreatmentWith Constitutional Mismatch Repair Deficiency Syndrome In Siblings: Secondary Malignancies After ALL & Treatment. National Journal of Integrated Research in Medicine, 7(2), 44–51. Retrieved from http://www.nicpd.ac.in/ojs-/index.php/njirm/article/view/1355
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