Effectiveness Of Blood Transfusion Therapy And Awareness Among Kinfolks Of Thalassemia Patients Visiting A Tertiary Care Hospital In North India
Effectiveness Of Blood Transfusion Therapy
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Effectiveness Of Blood Transfusion TherapyAbstract
The thalassemia is the most prevalent monogenic disease occurring at a high gene frequency throughout the thalassemia belt extending from Western Europe to Southeast Asia1. India, being ethnically diverse, frequency varies between several populations of different regions, averaging between 3-4%2. β-thalassemias are characterized by decreased synthesis of β globin chain of adult haemoglobin (HbA) resulting in transfusion dependant anaemia ,ineffective erythropoiesis, bone deformities with abnormal facies, hepatosplenomegaly and iron overload3.
References
1. Simon TL, Synder EL, Solheim BG, Stowel CP, Strauss RG, Petrides M. Rossi’s Principles of Transfusion Medicine, 4th ed. Blackwell publishing press; 2009.p.461.
2. Mohanty D, Colah RB, Gorakshakar AC, Patel RZ ,Master DC, Mahanta J et al. Prevalence of β-thalassemia and other haemoglobinopathies in six cities in India: a multicentric study. J Community Genet. 2013; 4:33–42. 3. Hillyer CD, Silberstein LE, Ness PM, Anderson KC, Roback JD. Blood Banking and TransfusionMedicine, Basic Principles and Practice, 2nd ed. Churchill Livingstone Elsevier press; 2007.p 534.
4. Mittal K, Bedi RK, Sood T, Kaur P, Kaur G. Transfusion support to thalassemic patients in a resource poor setting: still a long way to go. Blood Cells Mol Dis. 2014 Sep; 53(3):97-8.
5. Singer ST, Wu V, Mignacca R, Kuypers FA, Morel P, Vichinsky EP. Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly Asian descent. Blood.2000; 96: 3369–73.
6. Chaudhari CN. Red cell alloantibodies in multiple transfused thalassaemia patients. MJAFI. 2011; 67:34–37.
2. Mohanty D, Colah RB, Gorakshakar AC, Patel RZ ,Master DC, Mahanta J et al. Prevalence of β-thalassemia and other haemoglobinopathies in six cities in India: a multicentric study. J Community Genet. 2013; 4:33–42. 3. Hillyer CD, Silberstein LE, Ness PM, Anderson KC, Roback JD. Blood Banking and TransfusionMedicine, Basic Principles and Practice, 2nd ed. Churchill Livingstone Elsevier press; 2007.p 534.
4. Mittal K, Bedi RK, Sood T, Kaur P, Kaur G. Transfusion support to thalassemic patients in a resource poor setting: still a long way to go. Blood Cells Mol Dis. 2014 Sep; 53(3):97-8.
5. Singer ST, Wu V, Mignacca R, Kuypers FA, Morel P, Vichinsky EP. Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly Asian descent. Blood.2000; 96: 3369–73.
6. Chaudhari CN. Red cell alloantibodies in multiple transfused thalassaemia patients. MJAFI. 2011; 67:34–37.
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Published
2018-01-24
How to Cite
Kaur, D., Doda, V., & Hemal, A. (2018). Effectiveness Of Blood Transfusion Therapy And Awareness Among Kinfolks Of Thalassemia Patients Visiting A Tertiary Care Hospital In North India: Effectiveness Of Blood Transfusion Therapy. National Journal of Integrated Research in Medicine, 7(5), 105–107. Retrieved from http://www.nicpd.ac.in/ojs-/index.php/njirm/article/view/1155
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