Lipid Profile In Diabetes Mellitus

Lipid Profile In Diabetes Mellitus

Authors

  • Sher Sankar Roy
  • Dr. Pragnesh H. Shah

Keywords:

Diabetes, Lipid profile, FBS, PPBS

Abstract

Background: The prevalence of diabetes is rapidly rising all over the world. India is not an exception. Alteration of serum lipids & complications is significant in diabetics which lead to micro and macrovascular diseases. Aims & Objective: To know the lipid profile pattern in diabetic patients.To identify high risk group so that they can be treated early for preventing complications. Method: Total 200 OPD & indoor diabetic patients visiting at Sir Takhtsinhji General Hospital, Bhavnagar from June 2014 to May 2015 were selected using certain criteria. Results:Type I patients have onset of Diabetes at an early age with longer duration but they have normal lipid profile. Type 2 patients have onset of Diabetes at late age but they have elevated levels of Triglyceride, Cholesterol, LDL, VLDL with low HDL. Obesity is common in NIDDM.Females having higher lipid profile values than males. Uncontrolled Diabetic patients are more dyslipidemic. Interpretation & Conclusion: Type 1 diabetic patients have longer duration of disease. Type 2 diabetic patients having altered profile, having more risk for complications like atherosclerosis, Coronary Heart Disease etc. Control of Diabetes is necessary for controlling lipid profile & complications. [S S ROY NJIRM 2016; 7(4):8-13]

References

1. King H, Aubert R, Herman W. Global Burden of Diabetes, 1995-2025: Prevalence, numerical estimates, and projections. Diabetes Care. 1998;21(9):1414-1431.
2. Ramachandran A, Snehalatha C, Latha E, Vijay V, Viswanathan M. Rising prevalence of NIDDM in an urban population in India. Diabetologia. 1997;40(2):232-237.
3. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2006;30(Supplement 1):S42-S47.
4. Pasternak R. National Cholesterol Education Program (NCEP) Guidelines on the Detection, Evaluation and Treatment of Elevated Cholesterol in Adults: Adult Treatment Panel III (ATP III). ACC Current Journal Review. 2002;11(4):37-45.
5. Nagpal JBhartia A. Cardiovascular risk profile of subjects with known diabetes from the middle- and high-income group population of Delhi: the DEDICOM survey. Diabetic Medicine. 2007;0(0):071119221323005-???.
6. Reaven Greenfield M. Diabetic Hypertriglyceridemia: Evidence for Three Clinical Syndromes. Diabetes. 1981;30(Supplement_2):66-75.
7. Gale EGillespie K. Diabetes and gender. Diabetologia. 2001;44(1):3-15.
8. Ramaiya K, Kodali V, Alberti K. Epidemiology of diabetes in Asians of the Indian subcontinent. Diabetes Metab Rev. 1990;6(3):125-146. Feitosa A, Feitosa-Filho G, Freitas F, Wajchenberg B, Maranhão R. Lipoprotein metabolism in patients with type 1 diabetes under intensive insulin treatment. Lipids Health Dis. 2013;12(1):15.
9. Prato S, Matsuda M, Simonson D, Groop L, Sheehan P, Leonetti F et al. Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance. Diabetologia. 1997;40(6):687-697.
10. Gatineau et al . Adult obesity and type 2 diabetes. Public Health England J. 2014(7)
11. Guy J, Ogden L, Wadwa R, Hamman R, Mayer-Davis E, Liese A et al. Lipid and Lipoprotein Profiles in Youth With and Without Type 1 Diabetes: The SEARCH for Diabetes in Youth Case-Control Study. Diabetes Care. 2008;32(3):416-420.
12. Maahs D, Hokanson J, Wang H, Kinney G, Snell-Bergeon J, East A et al. Lipoprotein Subfraction Cholesterol Distribution Is Proatherogenic inWomen With Type 1 Diabetes and Insulin Resistance. Diabetes. 2010;59(7):1771-1779.
13. Kanagalakshmi K A Preliminary Study Of Lipid Profiles In Pediatric Population And Youth Population With Type I Diabetes. International Journal of Pharma and Bio Sciences. 2012;3(2)
14. Perez A, Carreras G, Caixas A, Castellvi A, Caballero A, Bonet R et al. Plasma Lipoprotein(a) Levels Are Not Influenced by Glycemic Control in Type 1 Diabetes. Diabetes Care. 1998;21(9):1517-1520.
15. Lassenius M, Mäkinen V, Fogarty C, Peräneva L, Jauhiainen M, Pussinen P et al. Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals. Nutrition & Metabolism. 2014;11(1):28
16. Feitosa A, Feitosa-Filho G, Freitas F, Wajchenberg B, Maranhão R. Lipoprotein metabolism in patients with type 1 diabetes under intensive insulin treatment. Lipids Health Dis. 2013;12(1):15
17. Eckel R, Albers J, Cheung M, Wahl P, Lindgren F, Bierman E. High density lipoprotein composition in insulin-dependent diabetes mellitus. Diabetes. 1981;30(2):132-138.
18. Tangvarasittichai et al. Serum lipoprotein ratios associated with insulin resistance. Indian J Med Res. 2010 (131);641-648
19. LathaPushparajJKirubakaran S. H b A 1 C AS A PREDICTOR OF LIPID PROFILE IN TYPE 2 DIABETIC PATIENTS. Journal of Evolution of Medical and Dental Sciences. 2014;3(12):3157-3165.
20. Agarwal P et al. Urban-Rural Differences in AtherogenicDyslipidaemia (URDAD Study): A Retrospective Report on Diabetic and Non-diabetic Subjects of Northern India. J.HEALTH POPUL NUTR 2014;32(3):494-502
21. NikkilaEHormila P. Serum Lipids and Lipoproteins in Insulin-treated Diabetes: Demonstration of Increased High Density Lipoprotein Concentrations. Diabetes. 1978;27(11):1078-1086.
22. Soedamah-Muthu S, Chaturvedi N, Toeller M, Ferriss B, Reboldi P, Michel G et al. Risk Factors for Coronary Heart Disease in Type 1 Diabetic Patients in Europe: The EURODIAB Prospective Complications Study. Diabetes Care. 2004;27(2):530-537.
23. Abdel-Aal et al. Prevalence of dyslipidemia in patients with type 2 diabetes in Jordan. Saudi Med J 2008; 29 (10)
24. Ladeia A, Adan L, Couto-Silva A, Hiltner Â, Guimarães A. Lipid Profile Correlates With Glycemic Control in Young Patients With Type 1 Diabetes Mellitus. Preventive Cardiology. 2006;9(2):82-88.
25. (24) Guy J, Ogden L, Wadwa R, Hamman R, Mayer-Davis E, Liese A et al. Lipid and Lipoprotein Profiles in Youth With and Without Type 1 Diabetes: The SEARCH for Diabetes in Youth Case-Control Study. Diabetes Care. 2008;32(3):416-420.

Downloads

Published

2018-01-22

How to Cite

Roy, S. S., & Shah, D. P. H. (2018). Lipid Profile In Diabetes Mellitus: Lipid Profile In Diabetes Mellitus. National Journal of Integrated Research in Medicine, 7(4), 8–13. Retrieved from http://www.nicpd.ac.in/ojs-/index.php/njirm/article/view/1095

Issue

Section

Original Articles