Study Of Diagnostic Efficacy Of Adenosine Deaminase (ADA) Levels In Tubercular Pleural Effusion
Study Of Diagnostic Efficacy Of Adenosine Deaminase (ADA) Levels In Tubercular Pleural Effusion
Keywords:
TB Pleural Effusion, Adenosine Deaminase, Mycobacterium tuberculosisAbstract
Background: Pleural effusion due to tuberculosis is common in countries like India where it is highly
endemic, however the organism is seldom detectable from plural fluid. The diagnosis of pleural tuberculosis has been
greatly improved by the use of biochemical markers. Activity of adenosine deaminase (ADA) in the pleural fluid is one
of the best providing reliable basis for a treatment decision, particularly in excluding the diagnosis of tuberculosis,
due to its high Sensitivity. The present study was aimed to evaluate the diagnostic use of Adenosine Deaminase
(ADA) levels in pleural effusion due to TB. Methodology: The study is a clinical, prospective and observational study
of 50 Patients of Pleural Effusion consecutively admitted in Department of Medicine, Ashwini rural Medical College
and hospital, Kumbhari from Jan 2013 to Dec 2013. Macroscopic findings, cytological study, microbiological and
biochemical analysis of pleural fluid were performed, including ADA levels. Results: Mean age group was 37 years and
common in men. In our study, out of 32 patients with tuberculosis pleural fluid ADA was done in them and 29
(90.63%) of them had a level more than 40IU/L. Using a cut off of greater 40IU/L we got a sensitivity and specificity of
93% and 90% respectively and Positive predictive value 93% and Negative predictive value 90%. Conclusion: All
patients with TB Pleural effusion had elevated ADA levels and there was a statistical significant association (p value
<0.05) of ADA levels in differentiating TB pleural effusion from Non-TB pleural effusion. [Golwalkar J.K NJIRM 2016;
7(3):12 - 16]
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